LNPs consist of ionizable lipids, which are critical for encapsulating RNA and enabling cellular uptake. Helper lipids contribute to the structural integrity and fusion with cell membranes.

Researchers developed a simulation showing how lipid nanoparticles release mRNA in acidic endosomes. The study reveals how ...

A study from FAU has shown that lipid nanoparticles restructure their membrane significantly after being absorbed into a cell ...

Lipid-based nanoparticles are a popular research area as a non-viral platform for delivering RNA molecules and include liposomes, lipoplexes, lipid nanoparticles and solid lipid nanoparticles. Using ...

In drug development many applications are found for lipid-based nanoparticles (Lb-NPs) as successful transporters for poorly water-soluble drugs and oligonucleotides in gene therapy. Major advantages ...

Liposomes and lipid nanoparticles (LNPs) are versatile drug delivery systems that allow precise control over composition, morphology, and structure, tailoring these features to meet specific ...

Johns Hopkins researchers have identified minuscule particles that supercharge therapeutic cancer vaccines, which train the immune system to attack tumors. These new lipid nanoparticles—tiny ...

The earliest iteration of LNPs was the development of liposomes in the 1960s, with the first liposome-based drug product, Doxil, receiving FDA approval in 1995. In the early 1990s, a second generation ...

Therapeutics that use mRNA - like some of the COVID-19 vaccines - have enormous potential for the prevention and treatment of many diseases. These therapeutics work by shuttling mRNA 'instructions' ...

Researchers at Johns Hopkins have discovered small particles that enhance therapeutic cancer vaccinations, which train the immune system to fight cancerous growths. These novel fat-based nanoparticles ...