Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for ...
Scientists at Duke-NUS Medical School and the National University Health System (NUHS), together with an international team ...
A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the ...
In mantle cell lymphoma (MCL), an aggressive form of B-cell non-Hodgkin lymphoma, TP53 mutations are known to affect patients’ prognosis—but questions remain. What does the heterogeneity of TP53 ...
From the time we are conceived and through old age, genetic mutations accumulate in all our tissues, eluding the body’s typically efficient DNA repair machinery and potentially affecting our health ...
Your body contains trillions of cells, each carrying out specific functions to keep you alive. According to a 2016 article in PLOS Biology, about 97% of these cells are made up of red blood cells, ...
New research finds that retinal diseases thought to map one-to-one to genetic mutations are more complicated than that.
Duke-NUS and NUHS scientists uncover a complex web of genetic, age-related and microbial factors that increase the risk of stomach cancer.Age-related blood cell mutations may trigger early changes in ...