A riboswitch can adopt different secondary structures to effect gene regulation depending on whether ligand is bound. This schematic is an example of a riboswitch that controls transcription. When ...
In a discovery that points to potential new antibiotic medicines, scientists from Rice University and the University of Michigan have deciphered the workings of a common but little-understood ...
Purine riboswitches have served as models for riboswitch structure, dynamics, evolution and engineering. New crystallographic models reveal the adaptability of a purine riboswitch evolved to bind ...
To prevent a global health crisis, scientists around the world are searching for ways to fight bacteria that can evade the current arsenal of antibiotics. A promising target for new and improved ...
RNA self-regulation is as complex and sophisticated as protein-based gene regulation, according to a report in Science this week. A novel Bacillus subtilis riboswitch as described by the authors is an ...
A research team at Merck (accidentally) uncovered a new antibacterial target - a riboswitch important for riboflavin (vitamin B2) biosynthesis. The team screened nearly 60,000 small molecules for ...
The survival of the cell is -- apart from other important aspects -- a question of timing. Scientists have now identified the different parts of this mechanism and introduced a model of the process.
In a discovery that points to potential new antibiotic medicines, scientists have deciphered the workings of a common but little-understood bacterial switch that cuts off protein production. In a ...
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Single-molecule FRET studies on the cotranscriptional folding of a thiamine pyrophosphate riboswitch
This is a preview. Log in through your library . Abstract Because RNAs fold as they are being synthesized, their transcription rate can affect their folding. Here, we report the results of ...
Novel Synthetic Riboswitch Platform Reversibly Regulates Gene Expression to High Dynamic Range and Drives Precise Dose Responsive Activation of Transgene Expression In Vivo LONDON and NEW YORK, Oct.
The last time I spoke about MeiraGTx Holdings plc (MGTX), it was in a Seeking Alpha article entitled "MeiraGTx: 2 Possible Near-Term BLA Filings Could Ignite Shareholder Value." With respect to this ...
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