"Using 2 complementary methods, we demonstrated that T cells in the lung tumor microenvironment do, in fact, demonstrate evidence of poor immune function." — Brinda Emu, MD, Yale University School of ...

The tumor microenvironment (TME) consists of mediators surrounding a tumor, including diverse cell types, blood vessels, and other cellular components. Certain elements of the TME can benefit patients ...

Existing oncology therapeutics are either so specific they can target only part of a tumor, or so generalized they kill healthy tissue. A new “Tumor Activated Therapy™” in development at the small ...

Despite progress in cancer biology, deciphering the spatial architecture of the tumor microenvironment remains a challenge. Traditional approaches lack the resolution to map cell-type-specific gene ...

Over the past decade, the advent of immune checkpoint blockade (ICB) therapy has transformed cancer treatment. Unlike conventional cytotoxic and targeted therapies, immunotherapy leverages both the ...

No tumor is an island. In the past two decades, it’s become increasingly appreciated that cancers are dependent on neighboring cells for their growth and survival. These tumor-friendly communities—or ...

Pancreatic cancer cells are known for being hard to treat, partly because they change the environment around them to block drugs and immune cells. Scientists discovered that these tumors use a ...

Recent advances in cancer treatment highlight the potential of natural medicines to target the tumor vascular microenvironment, offering a novel strategy to inhibit tumor growth and metastasis. Unlike ...

The tumor microenvironment is not just a site of cancer growth—it is a high-stakes metabolic contest where tumor and immune cells vie for limited resources. Amino acids, once seen as passive nutrients ...