A study from FAU has shown that lipid nanoparticles restructure their membrane significantly after being absorbed into a cell ...

Researchers developed a simulation showing how lipid nanoparticles release mRNA in acidic endosomes. The study reveals how ...

LNPs consist of ionizable lipids, which are critical for encapsulating RNA and enabling cellular uptake. Helper lipids contribute to the structural integrity and fusion with cell membranes.

UCLA researchers have developed a lipid nanoparticle-based gene-editing approach capable of inserting an entire healthy gene into human airway cells, restoring key biological function in a laboratory ...

Lipid nanoparticle formulation has increased over the past two decades. LNPs have proven to be effective nano-based delivery vehicles for cytotoxic chemotherapeutic drugs, nucleic acid therapies and ...

Researchers at Johns Hopkins have discovered small particles that enhance therapeutic cancer vaccinations, which train the immune system to fight cancerous growths. These novel fat-based nanoparticles ...

Capstan Therapeutics scientists demonstrate that lipid nanoparticles can engineer CAR T cells within the body without laboratory cell manufacturing and ex vivo expansion. The method using targeted ...

Messenger ribonucleic acid (mRNA)-based therapeutics and the potential of mRNA as a treatment for various conditions has been researched for decades. A key challenge remains finding a delivery system ...