Integrating AI with advanced robotics to create self-driving labs (SDL) is a promising approach to tackling molecular discovery. A new SDL system, called LUMI-lab, combines large-scale molecular ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction, which the ...

Integrating AI with advanced robotics to create self-driving labs (SDL) is a promising approach to tackling molecular discovery. A new SDL ...

Just as a chef perfects a dish by experimenting with flavors and textures, the researchers used an iterative process, testing variations to find the ideal structure for the ionizable lipid. This lipid ...

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal “recipe” for ionizable lipids — key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 ...

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal "recipe" for ionizable lipids - key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 ...

Experiments reveal that unsaturated lipid membranes promote vesicle fusion and DNA retention during freeze–thaw cycles, highlighting icy environments as potential drivers of protocell evolution. Today ...

New research finds that sleep is essential for protecting brain mitochondria by transferring toxic metabolic waste from neurons to glial cells for disposal.

Ekin Atilla-Gokcumen is a chemical biologist who studies lipids, a class of organic molecules that includes fats, waxes and sterols like cholesterol. Atilla-Gokcumen is among scientists whose work has ...

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal "recipe" for ionizable lipids—key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 ...