Malignant cells are genetically unstable and prone to develop chemotherapy resistance, whereas tumor vasculature is usually of host origin and genetically stable. Tumor endothelial microvessels ...

Many cells comprise the tumor microenvironment, but endothelial cells are particularly crucial. They line blood vessels, regulating blood flow and inflammation, and their cell junctions are the ...

BACKGROUND: The disruption of the blood–brain barrier (BBB) is a central pathogenic event in many central nervous system disorders. However, the mechanisms regulating BBB function remain incompletely ...

The innermost layer of blood vessels is formed by endothelial cells, which in turn play a role in the development of diseases of the cardiovascular system. Human endothelial cells are therefore ...

The endothelial glycocalyx integrates mechanical signals with vascular biology, playing a vital role in health and disease, ...